Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Shh  sonic hedgehog   (Synonyms: Hhg1)
Results	Reference
1*	J:198100 Andreeva V, Cardarelli J, Yelick PC, Rb1 mRNA expression in developing mouse teeth. Gene Expr Patterns. 2012 Mar-Apr;12(3-4):130-5
1	J:291194 Aryal YP, Neupane S, Adhikari N, An CH, Ha JH, Kwon TY, Yamamoto H, Jung JK, Park EK, Kim JY, Cho SW, Sohn WJ, Lee Y, Chae HJ, Kim HR, Kim JY, An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar. J Cell Physiol. 2019 Nov;234(11):20354-20365
1	J:149988 Beites CL, Hollenbeck PL, Kim J, Lovell-Badge R, Lander AD, Calof AL, Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development. 2009 Jul;136(13):2187-97
1*	J:38383 Bellusci S, Furuta Y, Rush MG, Henderson R, Winnier G, Hogan BL, Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development. 1997 Jan;124(1):53-63
1*	J:88802 Berman DM, Desai N, Wang X, Karhadkar SS, Reynon M, Abate-Shen C, Beachy PA, Shen MM, Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol. 2004 Mar 15;267(2):387-98
1*	J:29671 Bitgood MJ, McMahon AP, Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. 1995 Nov;172(1):126-38
1	J:262819 Bohnenpoll T, Feraric S, Nattkemper M, Weiss AC, Rudat C, Meuser M, Trowe MO, Kispert A, Diversification of Cell Lineages in Ureter Development. J Am Soc Nephrol. 2017 Jun;28(6):1792-1801
1	J:282102 Canizares MA, Albors AR, Singer G, Suttie N, Gorkic M, Felts P, Storey KG, Multiple steps characterise ventricular layer attrition to form the ependymal cell lining of the adult mouse spinal cord central canal. J Anat. 2019 Oct 31;
1	J:239874 Christ A, Christa A, Klippert J, Eule JC, Bachmann S, Wallace VA, Hammes A, Willnow TE, LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli. Dev Cell. 2015 Oct 12;35(1):36-48
1*	J:150375 Cobourne MT, Xavier GM, Depew M, Hagan L, Sealby J, Webster Z, Sharpe PT, Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome. Dev Biol. 2009 Jul 1;331(1):38-49
1	J:163224 Garcia-Lopez M, Abellan A, Legaz I, Rubenstein JL, Puelles L, Medina L, Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol. 2008 Jan 1;506(1):46-74
1*	J:75698 Grunder A, Ebel TT, Mallo M, Schwarzkopf G, Shimizu T, Sippel AE, Schrewe H, Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77
1	J:217375 Heavner WE, Andoniadou CL, Pevny LH, Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling. Neural Dev. 2014;9:27
1	J:152851 Huang X, Ketova T, Fleming JT, Wang H, Dey SK, Litingtung Y, Chiang C, Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development. 2009 Aug;136(15):2535-43
1	J:160335 Huang X, Liu J, Ketova T, Fleming JT, Grover VK, Cooper MK, Litingtung Y, Chiang C, Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8422-7
1	J:214032 Ishida K, Yuge Y, Hanaoka M, Yasukawa M, Minami Y, Ogawa M, Masumoto KH, Shigeyoshi Y, Saito M, Tsuji T, Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression. Genes Cells. 2013 Aug;18(8):660-71
1	J:108713 Itaranta P, Chi L, Seppanen T, Niku M, Tuukkanen J, Peltoketo H, Vainio S, Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney. Dev Biol. 2006 May 15;293(2):473-83
1	J:119729 Iwatsuki K, Liu HX, Gronder A, Singer MA, Lane TF, Grosschedl R, Mistretta CM, Margolskee RF, Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2253-8
1	J:118173 Jarvinen E, Salazar-Ciudad I, Birchmeier W, Taketo MM, Jernvall J, Thesleff I, Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18627-32
1	J:260962 Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A, Essential roles of G9a in cell proliferation and differentiation during tooth development. Exp Cell Res. 2017 Aug 15;357(2):202-210
1	J:54912 Karlsson L, Bondjers C, Betsholtz C, Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle. Development. 1999 Jun;126(12):2611-21
1*	J:260416 Kibe K, Nakatomi M, Kataoka S, Toyono T, Seta Y, Hey1 and Hey2 are differently expressed during mouse tooth development. Gene Expr Patterns. 2018 Jan;27:99-105
1	J:155826 King P, Paul A, Laufer E, Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21185-90
1	J:130572 Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR, An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development. 2008 Jan;135(2):377-85
1	J:151258 Kolterud A, Grosse AS, Zacharias WJ, Walton KD, Kretovich KE, Madison BB, Waghray M, Ferris JE, Hu C, Merchant JL, Dlugosz AA, Kottmann AH, Gumucio DL, Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology. 2009 Aug;137(2):618-28
1	J:114152 Kuraguchi M, Wang XP, Bronson RT, Rothenberg R, Ohene-Baah NY, Lund JJ, Kucherlapati M, Maas RL, Kucherlapati R, Adenomatous Polyposis Coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2(9):e146
1	J:187316 Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M, BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012;7(5):e37670
1	J:175843 Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA, Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell. 2011 Aug 16;21(2):315-27
1	J:178364 Lenton K, James AW, Manu A, Brugmann SA, Birker D, Nelson ER, Leucht P, Helms JA, Longaker MT, Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis. 2011 Oct;49(10):784-96
1	J:214993 Lin C, Chen MH, Yao E, Song H, Gacayan R, Hui CC, Chuang PT, Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development. Dev Biol. 2014 Aug 15;392(2):324-33
1	J:218941 Meier F, Giesert F, Delic S, Faus-Kessler T, Matheus F, Simeone A, Holter SM, Kuhn R, Weisenhorn DM, Wurst W, Prakash N, FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum. PLoS One. 2014;9(7):e101124
1	J:126364 Merchan P, Bribian A, Sanchez-Camacho C, Lezameta M, Bovolenta P, de Castro F, Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors. Mol Cell Neurosci. 2007 Nov;36(3):355-368
1*	J:86666 Michno K, Boras-Granic K, Mill P, Hui CC, Hamel PA, Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol. 2003 Dec 1;264(1):153-65
1	J:100687 Mill P, Mo R, Hu MC, Dagnino L, Rosenblum ND, Hui CC, Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell. 2005 Aug;9(2):293-303
1	J:309402 Nakamura T, Jimenez-Rojo L, Koyama E, Pacifici M, de Vega S, Iwamoto M, Fukumoto S, Unda F, Yamada Y, Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development. J Bone Miner Res. 2017 Mar;32(3):601-610
1*	J:137801 Nakayama A, Miura H, Shindo Y, Kusakabe Y, Tomonari H, Harada S, Expression of the basal cell markers of taste buds in the anterior tongue and soft palate of the mouse embryo. J Comp Neurol. 2008 Jul 10;509(2):211-24
1*	J:297164 Nie X, Zheng J, Cruciger M, Yang P, Mao JJ, mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87
1	J:160263 Nielsen CM, Dymecki SM, Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol. 2010 Apr 15;340(2):430-7
1	J:144348 Ohazama A, Johnson EB, Ota MS, Choi HJ, Porntaveetus T, Oommen S, Itoh N, Eto K, Gritli-Linde A, Herz J, Sharpe PT, Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One. 2008;3(12):e4092
1	J:185279 Paces-Fessy M, Fabre M, Lesaulnier C, Cereghini S, Hnf1b and Pax2 cooperate to control different pathways in kidney and ureter morphogenesis. Hum Mol Genet. 2012 Jul 15;21(14):3143-55
1	J:163175 Rice DP, Connor EC, Veltmaat JM, Lana-Elola E, Veistinen L, Tanimoto Y, Bellusci S, Rice R, Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet. 2010 Sep 1;19(17):3457-67
1	J:85949 Shikama N, Lutz W, Kretzschmar R, Sauter N, Roth JF, Marino S, Wittwer J, Scheidweiler A, Eckner R, Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J. 2003 Oct 1;22(19):5175-85
1*	J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1	J:121421 Shu W, Lu MM, Zhang Y, Tucker PW, Zhou D, Morrisey EE, Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development. 2007 May;134(10):1991-2000
1	J:161718 Suzuki Y, Ikeda K, Kawakami K, Regulatory role of Six1 in the development of taste papillae. Cell Tissue Res. 2010 Mar;339(3):513-25
1	J:288236 Takahashi M, Ikeda K, Ohmuraya M, Nakagawa Y, Sakuma T, Yamamoto T, Kawakami K, Six1 is required for signaling center formation and labial-lingual asymmetry in developing lower incisors. Dev Dyn. 2020 Apr 3;
1	J:159209 Tornqvist G, Sandberg A, Hagglund AC, Carlsson L, Cyclic expression of lhx2 regulates hair formation. PLoS Genet. 2010;6(4):e1000904
1	J:149542 Wang XP, O'Connell DJ, Lund JJ, Saadi I, Kuraguchi M, Turbe-Doan A, Cavallesco R, Kim H, Park PJ, Harada H, Kucherlapati R, Maas RL, Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development. 2009 Jun;136(11):1939-49
1	J:91704 Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Wankell M, Werner S, Thesleff I, Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth. Dev Dyn. 2004 Sep;231(1):98-108
1	J:195784 Xavier GM, Panousopoulos L, Cobourne MT, Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse. PLoS One. 2013;8(1):e55274
1	J:140401 Xu X, Han J, Ito Y, Bringas P Jr, Deng C, Chai Y, Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev Cell. 2008 Aug;15(2):322-9
1	J:309435 Zhang B, Tsai PC, Gonzalez-Celeiro M, Chung O, Boumard B, Perdigoto CN, Ezhkova E, Hsu YC, Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog. Genes Dev. 2016 Oct 15;30(20):2325-2338
1	J:266585 Zheng J, Nie X, He L, Yoon AJ, Wu L, Zhang X, Vats M, Schiff MD, Xiang L, Tian Z, Ling J, Mao JJ, Epithelial Cdc42 Deletion Induced Enamel Organ Defects and Cystogenesis. J Dent Res. 2018 Nov;97(12):1346-1354